You can use the CellBinding event to hook custom commands for grid columns - for example Save / Edit / Cancel for grid row editing.

Please, review the ASPX/C# code tabs for details.
<%@ Page Language="C#" AutoEventWireup="true" CodeBehind="default.aspx.cs" Inherits="JQSuiteASPNETExample.examples.editing_data.custom_edit_buttons._default" %>
<%@ Register Assembly="Trirand.Web" TagPrefix="trirand" Namespace="Trirand.Web.UI.WebControls" %>

<!DOCTYPE html>
<html lang="en-us">
<head id="Head1" runat="server">
    <meta charset="utf-8">
    <title>jqGrid for ASP.NET WebForms - custom edit buttons</title>
    <!-- The jQuery UI theme that will be used by the grid -->
    <link rel="stylesheet" type="text/css" media="screen" href="" />
    <!-- The jQuery UI theme extension jqGrid needs -->
    <link rel="stylesheet" type="text/css" media="screen" href="/themes/ui.jqgrid.css" />
    <!-- jQuery runtime minified -->
    <script src="/js/jquery-3.2.1.min.js" type="text/javascript"></script>
    <!-- The localization file we need, English in this case -->
    <script src="/js/trirand/i18n/grid.locale-en.js" type="text/javascript"></script>
    <!-- The jqGrid client-side javascript -->
    <script src="/js/trirand/jquery.jqGrid.min.js" type="text/javascript"></script>    
    <style type="text/css">
        body, html { font-size: 80%; }    
    <form id="form1" runat="server">
       <trirand:JQGrid ID="JQGrid1" runat="server" Width="600px" 
            OnRowEditing="JQGrid1_RowEditing" oncellbinding="JQGrid1_CellBinding" 
                <trirand:JQGridColumn DataField="EmployeeID" Editable="false" PrimaryKey="true" Width="50"/>                
                <trirand:JQGridColumn DataField="FirstName" Editable="true" />
                <trirand:JQGridColumn DataField="LastName" Editable="true" />
                <trirand:JQGridColumn DataField="City" Editable="true" />
                <trirand:JQGridColumn HeaderText="Edit" />
                <trirand:JQGridColumn HeaderText="Save" />
                <trirand:JQGridColumn HeaderText="Cancel" />                
       <br />
       <input type="button" onclick="addNewRow()" value="Add New Row" />
       <script type="text/javascript">
       function addNewRow()
          var grid = $("#<%= JQGrid1.ClientID %>");
       <br /><br />
       <trirand:codetabs runat="server" id="DataTableCodeTabs"></trirand:codetabs>    

using System;
using System.Collections.Generic;
using System.Linq;
using System.Web;
using System.Web.UI;
using System.Web.UI.WebControls;
using System.Data;
using System.Data.SqlClient;
using System.Configuration;
using Trirand.Web.UI.WebControls;

namespace JQSuiteASPNETExample.examples.editing_data.custom_edit_buttons
    public partial class _default : System.Web.UI.Page
        protected void Page_Load(object sender, EventArgs e)
            if (JQGrid1.AjaxCallBackMode == AjaxCallBackMode.RequestData)
                JQGrid1.DataSource = GetData();

        protected void JQGrid1_RowAdding(object sender, JQGridRowAddEventArgs e)


        protected void JQGrid1_RowEditing(object sender, Trirand.Web.UI.WebControls.JQGridRowEditEventArgs e)
            DataTable dt = GetData();
            dt.PrimaryKey = new DataColumn[] { dt.Columns["EmployeeID"] };
            DataRow rowEdited = dt.Rows.Find(e.RowKey);

            rowEdited["FirstName"] = e.RowData["FirstName"];
            rowEdited["LastName"] = e.RowData["LastName"];
            rowEdited["City"] = e.RowData["City"];

            JQGrid1.DataSource = GetData();

        protected DataTable GetData()
            if (Session["InlineEditGridData"] == null)
                // Create a new Sql Connection and set connection string accordingly
                SqlConnection sqlConnection = new SqlConnection();
                sqlConnection.ConnectionString = ConfigurationManager.ConnectionStrings["SQL2008_661086_trirandEntities"].ConnectionString;

                string sqlStatement = "SELECT EmployeeID, FirstName, LastName, City FROM Employees";

                // Create a SqlDataAdapter to get the results as DataTable
                SqlDataAdapter sqlDataAdapter = new SqlDataAdapter(sqlStatement, sqlConnection);

                // Create a new DataTable
                DataTable dtResult = new DataTable();

                // Fill the DataTable with the result of the SQL statement

                Session["InlineEditGridData"] = dtResult;

                return dtResult;
                return Session["InlineEditGridData"] as DataTable;

        protected void JQGrid1_CellBinding(object sender, Trirand.Web.UI.WebControls.JQGridCellBindEventArgs e)
            string editLink = "Edit";
            string saveLink = "Save";
            string cancelLink = "Cancel";

            if (e.ColumnIndex == 4) // edit
                e.CellHtml = String.Format(editLink, JQGrid1.ClientID, e.RowKey);
            if (e.ColumnIndex == 5) // save
                e.CellHtml = String.Format(saveLink, JQGrid1.ClientID, e.RowKey);
            if (e.ColumnIndex == 6) // cancel
                e.CellHtml = String.Format(cancelLink, JQGrid1.ClientID, e.RowKey);

Switch theme:

Theming is based on the very popular jQuery ThemeRoller standard. This is the same theming mechanism used by jQuery UI and is now a de-facto standard for jQuery based components. The benefits of using ThemeRoller are huge. We can offer a big set of ready to use themes created by professional designers, including Windows-like themes (Redmond), Apple-like theme (Cupertino), etc. In addition to that any jQuery UI controls on the same page will pick the same theme.

Last, but not least, you can always roll your own ThemeRoller theme, using the superb Theme Editor

To use a theme, simply reference 2 Css files in your Html <head> section - the ThemeRoller theme you wish to use, and the jqGrid own ThemeRoller Css file. For example (Redmond theme):

<link rel="stylesheet" type="text/css" media="screen" href="/themes/redmond/jquery-ui-1.8.2.custom.css" />
<link rel="stylesheet" type="text/css" media="screen" href="/themes/ui.jqgrid.css" />